Keothavong and Baltacha reach Aussie Open second round
Keothavong reached the second round for the first time after overcoming Russian Arina Rodionova 7-5, 6-4.
Fellow Brit Baltacha came from a set down to beat American Jamie Hampton 3-6,6-4,7-5.
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Hide AdKeothavong will now play German Andrea Petkovic in the second round and could face Venus Williams if victorious.
Meanwhile, Baltacha faces 11th seed Justin Henin who struggled to a three-set win against India's Sania Mirza.
Despite the daunting task ahead Baltacha remained upbeat: "I think I've got to believe I've got a chance, otherwise there's no point playing.
"The chances are probably slim, but I'm going to go out there and fire, I've got nothing to lose."
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Hide AdKeothavong was equally pleased. She said: "The conditiions were tough, but it's a great feeling to get through. I had a great off-season and just want to get out there and enjoy it."
Both players will play their second-round ties on Wednesday with Baltacha hoping to pull off a major upset and Keothavong attempting to set up a mouth watering clash with world No 5 Williams.